Singletons were discarded in order to minimize the number of false positives, as it is highly unlikely to obtain sequencing errors twice at the same base location.
In AGRE, however, many signals extended across multiple SNPs, a pattern highly unlikely to arise from genotyping error.
Frost says he raised concerns with MoD staff at Weeton "expressing his concern that the dispensing error was highly unlikely to have been a mistake and that he considered Mrs Gould to have been coerced into illegal activity, be it by threats or blackmail".
The presence of multiple SNPs with low P-values (P < 0.01) in strong LD with this SNP provides evidence that this signal is highly unlikely to be driven by genotyping error.
The reasons for this deviation are not clear; however, it is highly unlikely to be due to genotyping errors as the inclusion of the internal and external controls, and the blindedness of the laboratory personnel to the samples ensured accuracy of genotyping results.
Nonetheless, genotyping error is highly unlikely to produce signals of TD that span a broad region, encompassing many SNPs.
Fraser Armstrong, a chemist at the University of Oxford in the United Kingdom, who served as the president of SBIC from 2004 to 2006, also thinks "the mistake is most likely to be a technical error and is highly unlikely to have any mischievous motive".
This arrangement is highly unlikely to represent the actual genomic arrangement and is likely the result of an error in the assembly.
These changes are far from those caused by normal disturbances and are highly unlikely to be explained by minor issues such as price differences or random errors.
To the extent that this error is classical, simulation studies have shown that it is highly unlikely to bias away from the null even in the presence of covariates.
In contrast to the MUE, the DP4 metric rules out structures from consideration that have one or more significant errors in predicted H and/or C NMR chemical shift; under this metric diastereomer #1 is highly unlikely to be correct.
