The City of Seattle was already funding a highly-qualified, unbiased research team at the University of Washington to do such a report.
To understand the functions of the kidney, the transcriptome of each part of the nephron needs to be profiled using a highly sensitive and unbiased tool.
This analysis can provide necessary information for modeling and simulation efforts in the form of a highly refined and unbiased description of specific features, such as the distribution of grain size, shape and orientation.
SumGames - Odds and Probabilities is an assembly of all the unbiased, highly technical investment research on mutual fund portfolio probability to date.
Moreover, unlike microarrays and older methods, RNA-seq provides transcriptome-wide sequence coverage with unbiased, highly quantitative results [ 30] and greatly improved sensitivity [ 31, 32].
The plasticity of gene regulation networks makes them powerful readouts of genome-wide responses to perturbations; moreover, global gene expression measurement is relatively simple, highly quantitative and unbiased view of regulatory outputs.
Contrary to what is expected by chance (assuming that all transfer functions can be realized) the transfer functions of the inferred core network of S. cerevisiae appear to be highly biased (although unbiased overall).
Within the field of whole transcriptome sequencing, the primary benefit over traditional microarray is the capacity to read all expressed transcripts, yielding unbiased highly sensitive measurements, without the dependence on prior knowledge to specify probes.
By hybridizing DNase I-digested fragments to tiled microarrays, the DNase-chip assay provides an undirected, unbiased, highly sensitive and specific strategy to simultaneously identify thousands of DHSs within any region of interest or even the entire genome, with a resolution of 200 500 bases [ 7].
The highly conservative Approximately Unbiased (AU) test rejected all tested tree topologies with Pandoraviruses placed outside the Phycodnaviridae branch for the D5-like helicase-primase; for the other genes, some of the alternative topologies were not rejected by the AU test but all were assigned lower likelihood values (Additional file 2).
This paper develops an improved metamodel method which is unbiased and highly efficient.
