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More highly substituted carbocations are more stable (3° > 2° > 1°); therefore, more highly substituted alcohols undergo dehydration more readily than less highly substituted alcohols (3° > 2° > 1°).
As examples, highly substituted spirobenzophenanthridin-6 5H -ones spirobenzophenanthridin-6 5H -ones.
Chitin dihexanoate (DHCH) is the novel biocompatible and technologically friendly highly substituted chitin diester.
Also it was observed that the more highly substituted adsorbents exhibited higher affinity for proteins.
(The more highly substituted end of the double bond is the one that is bonded to more carbon atoms).
These are the consequence of associative behaviour due to hydrophobic interactions involving highly substituted units.
A replacement of the C-phenyl ring with a 5-membered ring in 21 was not tolerated and also highly substituted 22 showed poor inhibition (Fig. 4).
Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres.
Overall, the work presents fundamental studies on the synthesis and conformational properties of highly substituted, electronically rich THIQ3CA analogs.
These methods include the development of a novel cyclization utilizing alkynyl ketones or enones to give highly substituted pyrimidines.
A process design for the continuous production of highly substituted granular carboxymethyl starch (CMS) from potato starch is presented.
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