This highly simplistic assumption, substantiated by an enormous amount of evidence both from the point of view of the ribosome and that of the mitochondrion, will serve as a first approximation toward the analysis of the pathogenic potential of mt-rRNA mutations.
For example, simplified, monodimensional hypotheses on land-use intensification, for example, on the interrelationship between agricultural intensification and area demand, though initially highly intuitive, cannot be substantiated when evaluated against empirical data [ 18,19].
The suspicion of a functional defect has to be substantiated by highly specialized tests, which are expensive and performed in few laboratories, and is thus not always easily accessible in every country.
Because both ELISAs rely on detection of antibodies against RVFV N protein, which is highly divergent to the deduced NRIV N sequence, cross-reactivity is highly unlikely but needs to be substantiated.
This is substantiated by the occurrence of highly lignified cells in the exocarp of A. gregorii, as well (Bleechmore 2002).
This presupposition is substantiated by our finding of highly enhanced TCF-mediated transcriptional activity in the cell lines JROECL19 and JROECL33, both with nuclear β-catenin expression.
From the crystallographic study using the edge-to-edge matching model, electron backscatter diffraction and transmission electron microscopy, it is substantiated that the Al3Zr particles are highly potent nucleants for Al.
Such integrative efforts substantiated with experimental validation present a highly promising systems approach for elucidating the regulatory determinants of secondary metabolism.
Both effects, remain however insufficiently substantiated by scientific evidence and thus are highly controversial (for review see17, 18).
The retrieved studies include short-term and longer-term studies in humans, and a number of animal studies, which were highly heterogeneous in their design making it difficult to draw substantiated conclusions.
