In either case, the starting point for folding under native conditions is highly structured and already poised to adopt the native structure.
Strikingly, we found that pre-established late-stage biofilms formed under static conditions and mature highly structured biofilms formed under shear forces were quite efficiently disrupted by DNase I.
mRNAs translated under these conditions have a highly structured 50-untranslated region, which often harbors an Internal Ribosome Entry Site sequence and several upstream AUGs.
The mechanism of GATA1 suppression in DBA might involve the highly structured 5′ end of GATA1 mRNA that requires stringent conditions for translation initiation (Ludwig et al., 2014).
Conversely, under many modern farming conditions, potential hosts have low genetic diversity and highly structured age distribution and are regularly protected from some pathogens through vaccination and antimicrobial drugs.
Linking these lifestyle modifications to the individual's chronic condition and consequently providing a personalized and highly structured digital behavioral intervention could have a transformational effect on the individual's life, improving their quality of sleep and, as a result, their ability to function.
The chief examples of large-scale production by slaves were in mining and metallurgy, in which the conditions of labour were harsh and the organization of work was highly structured.
Deen and others described a kind of vertigo upon leaving the highly structured confines of a religious upbringing, and facing the onset of the modern condition, all at once, in which every person must carve out a destiny, and nothing is predetermined.
We see from Fig. 4 that the main effect of the Dirichlet boundary condition is to limit the spread of a labyrinthine structure and ultimately induce a highly structured stationary pattern, as expected.
Using the mutant protein L16A, a variant that is unfolded under conditions in which the wild-type sequence is native, the unfolded state was shown to be highly structured, possessing substantial amounts of native secondary and tertiary structure [19].
