Exact(8)
Second, use of radiotracers with more highly specific activity is more likely to ensure that the radiolabeled compound does not elicit any pharmacological effects when administered.
As such, the measurements by MALDI IMS differ from traditional molecular imaging of drugs by PET or autoradiography that require highly specific activity labels for detection and quantification.
The main advantage of Bti over chemical insecticides is its highly specific activity towards dipteran insects, due to the presence of membrane receptors in the insect gut serving as targets for the bacterial toxins [3], [6], [7].
The highly specific activity of this endoglycosidase increases pathogen survival in human blood containing opsonising antibodies [ 28- 30].
Notwithstanding these hurdles, we were able to demonstrate a highly specific activity of apocynin in the assay.
Starting from washed inclusion bodies we also developed an efficient refolding and purification protocol to obtain a final MTGase preparation which displayed highly specific activity.
Similar(52)
If people define precise times at which to do highly specific activities, these new behaviors eventually become automatic and no longer require conscious will and discipline.
In reports on the enzymatic activities of Man5A and Man5B it was demonstrated that Man5B and Man5A show highly specific activities with glucomannan as a substrate.
Pediocin is an active peptide with highly specific inhibitory activity against Listeria monocytogenes.
PP2Ac enriched with Zn2+ and Fe2+, both retained detectable levels of Mg2+, exhibited highly specific phosphatase activity towards pThr (Kcat = 360-460/min at 23 °C), while PP2Ac with increased Mn2+ occupancy exhibited higher phosphatase activity towards pNPP (p-nitrophenyl phosphate) (Kcat∼115/min at 37 °C), a chemical mimic of pTyr (Supplementary information, Figure S5A).
We developed a rapid, mass spectrometry based method (Endopep-MS) to detect and differentiate active BoNTs A, B, E, and F. This method uses the highly specific protease activity of the toxins with target peptides specific for each toxin serotype.
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