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In addition, a highly significant peak was observed at wavenumbers around 1240 cm−1, assigned to C-O vibrations in pectic polysaccharides [25].
Slightly upstream, a highly significant peak centred within EPS8.
QTL analysis revealed a highly significant peak (LOD = 7.6) (Fig. 1C) (Table S1).
The DArT-BSA scan for Al tolerance in the Dayton/Zhepi2 population revealed a highly significant peak on chromosome 4H, despite the elevated 'pooling-noise' threshold (50%; p < 0.05) due to the small bulk sizes used.
Comparing across subjects there was a highly significant peak in left central gamma immediately after the button press in each of the two cohorts as can be seen in Figs. 3b, 4 and 5.
Analysis of EBV-positive and -negative subgroups by Edwards' method revealed a highly significant peak onset of symptoms for EBV-positive patients occurring at the end of July/early August (θ=31°+180°=211°) with a trough at the beginning of February (θ=31°) (P=0.0093; Figure 1 ).
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To validate the ChIP-seq peaks in vhl, 20 highly significant peaks containing a HRE, were selected and ChIP-qPCR was performed using primers designed around the region containing the HRE.
A meta-analysis of genome-wide association studies and age-associated diseases has identified two highly significant peaks of disease association, mapping to the major histocompatibility locus and the INK4/ARF locus (Jeck et al., 2012).
Interestingly, two of the genes in this network have previously been associated with schizophrenia as deregulated in postmortem brains (CCND2 [39]) or positioned under a highly significant linkage peak (PTPN1[40]).
Two replicate samples of genomic DNA each extracted from 10 fliesies displaying heart failure in the testcross of NC1 by yw resulted in a highly significant linkage peak at the identical position on the right arm of chromosome 3 (Figure 3), consistent with the presence of a dominant susceptibility locus centered on the interval 97C in the NC1 line.
This region has shown a highly significant linkage peak with emotionality in mice (Flint et al. 1995).
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