Rohren et al showed that determination of skeletal tumour burden with 18F-fluoride PET/CT is feasible and highly reproducible regarding inter-observer reproducibility [13].
We then defined four classes of CVs for the genes (highly reproducible signals – CV < 0.25, good reproducibility – 0.25 < CV < 0.5, medium reproducibility – 0.5 < CV < 0.75 and poor reproducibility CV > 0.75).
Isoelectric focusing (IEF) has a high reproducibility due to use of highly reproducible commercial immobilized pH gradient (IPG) strip.
The pre-specified primary aim of the tissue reproducibility validation was to demonstrate the Prosigna assay is highly reproducible, when combining all sources of variation.
When the DNA input was at the recommended amount the method was highly reproducible, but when the DNA input decreased below 1 ng per test, reproducibility deteriorated.
Seven samples were run as experimental replicates to estimate assay reproducibility for which an average Pearson's R of 0.965 indicated highly reproducible data (Supplementary Figure 1).
In addition, age-associated DNAm changes, which are highly reproducible when using the IlluminaBeadChip platform [ 21, 34, 35], revealed much lower reproducibility in MethylCap-seq data [ 36].
Data reproducibility analyses comparing same-species to cross-species hybridization indicates that cross-species hybridizations are highly reproducible, thus increasing the confidence level in their specificity.
Despite the fact that the reproducibility of SUVs is affected by ROI size, SUV measurements obtained from large and fixed ROIs have been shown to be highly reproducible [20, 21].
In animal experiments, however, where the lives of animals are highly valuable, poor reproducibility is also an ethical issue.
