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We suspect that GFW may cause very early genotoxic stress responses in highly replicating cancer cells.
Retrotransposon-derived sequences in humans are developmentally regulated and effective retrotransposition occurs in highly replicating cells (embryos, tumors) [ 49].
This expression pattern is consistent with the known association of Phgdh with highly replicating cells as the first and rate-limiting step in de novo biosynthesis of serine [ 37], which also plays a role as nucleotide precursor in regenerating liver tissue and hepatomas [ 38].
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Chromosome 17q12-21 remains the most highly replicated and significant asthma locus.
In particular, the first phase is designed to reduce the search overhead and lookup delay in searching popular (highly replicated) files, and the second phase is designed to reduce the excessive duplicate messages in searching unpopular (rare) files.
The BF2 method provided rapid and precise estimations of %PAR under variable sky conditions, as well as good estimations of seedling's responses, and is suitable for multiple site or highly replicated designs.
We used a highly replicated study to examine vegetation characteristics between patches of intervened forest, abandoned agroforestry systems with coffee and actively managed agroforestry systems with coffee in a tropical landscape.
As a result, we have become a highly replicated program.
Even among this list of genes supported by highly replicated studies, results have not been consistent among all populations tested.
This paper breaks new ground in normalization and clustering methods for highly replicated temporal microarray data.
Associations of IRF5 (interferon regulator factor 5) genetic variants and increased SLE risk have been highly replicated [25].
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