Sentence examples for highly refractory to from inspiring English sources

It became clear to the attendees that in this wide range of conditions, there is a subset of patients that remain highly refractory to first line therapy.

Also, HT-29 colorectal tumor xenografts, which are highly refractory to paclitaxel, showed complete regression after AZ10992 administered at 30 mg/kg/day (seven injections for 4-days).

Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer death and has proved to be highly refractory to treatment.

Dr. Robert J. Motzer of Memorial Sloan-Kettering Cancer Center in New York, who was not involved in the study, said: "This is a novel treatment strategy that has produced encouraging results, in a cancer that is highly refractory to conventional therapy.

Thus, these two mutations demonstrated reciprocal host range phenotypes involving different regions of C. The CΔ170 mutation conferred a significant level of attenuation in hamsters and AGMs that closely resembled that of CF170S and will be of particular utility for vaccine development because it involves a deletion of six nucleotides rendering it highly refractory to reversion.

The decision to discontinue treatment has a heavy burden of consequences, given that CM can be highly refractory to treatment, disabling, and associated with comorbidities including depression, anxiety, and medication overuse [6, 7].

Addition of these highly refractory spores to the assays served as internal control for DNA isolation and amplification (see also [ 11, 12]).

First, cancers are often detected at a late stage in development, after multiple genetic and epigenetic changes have rendered the cancer metastatic and highly refractory even to harsh treatment.

Nevertheless, this was a group of RA patients who were highly active refractory to previous treatment.

Ixabepilone monotherapy was therefore active in patients with difficult-to-treat, advanced, highly refractory breast cancer who had failed to respond to prior chemotherapy.

Obviously, TRAIL provided stronger apoptotic stimuli than anti-CD95 since only the cell line PancTuI remained highly refractory (13.3% apoptosis) to TRAIL treatment whereas 24.6% of Panc1 cells, 35.6% of Panc89 cells, 68.1% of Colo357 cells and 86.3% of Capan1 cells died after 24 h exposition to TRAIL.