Because they are highly refractory, these compounds have been much investigated for use as fuels for nuclear reactors.
The furnace itself is made of highly refractory materials such as magnesite bricks for the hearths and roofs.
Often called ablation, this process is an effective means of vaporizing even highly refractory materials like solid carbon.
For heavy castings, molds made of coarse loam sand backed up with brick and faced with highly refractory material are used.
Dr. Robert J. Motzer of Memorial Sloan-Kettering Cancer Center in New York, who was not involved in the study, said: "This is a novel treatment strategy that has produced encouraging results, in a cancer that is highly refractory to conventional therapy.
In addition, they have had to develop special techniques with which to dissolve these highly refractory minerals without contaminating the small amount (about one-billionth of a gram) of contained lead and uranium on which the age must be calculated.
It became clear to the attendees that in this wide range of conditions, there is a subset of patients that remain highly refractory to first line therapy.
Also, HT-29 colorectal tumor xenografts, which are highly refractory to paclitaxel, showed complete regression after AZ10992 administered at 30 mg/kg/day (seven injections for 4-days).
Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer death and has proved to be highly refractory to treatment.
The decision to discontinue treatment has a heavy burden of consequences, given that CM can be highly refractory to treatment, disabling, and associated with comorbidities including depression, anxiety, and medication overuse [6, 7].
This method may be more at risk of being influenced by natural fluctuations in CM severity, however, in our cohort of highly refractory patients such fluctuations were not commonly seen prior to ONS.
