Sentence examples for highly recapitulated from inspiring English sources

Our data in human GBM were highly recapitulated in the preclinical GBM model and strongly suggest the involvement of angiopoietin signaling in the remodeling of the tumor environment, potentially by supporting several key events that not only include angiogenesis and vascular destabilization but additionally imply the infiltration and/or reeducation of TAMs, combined with immunosuppression.

The anti-inflammatory activity of SNA-enriched IVIG has been recapitulated with highly sialylated, recombinant human IgG1-Fc (Anthony et al., 2008a).

This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells.

This model recapitulates highly aggressive claudin-low (mesenchymal) TNBC chemoresistant breast cancer.

The complex intimate interactions in neurovascular and gliovascular units are highly difficult to recapitulate in vitro.

RNAi depletion of WRN, although highly effective in recapitulating some WS-like phenotypes (Dhillon et al., 2007), eliminates both helicase and exonuclease activities.

Studies using such models, and others including transplanted cell lines, often yield highly encouraging results which are seldom recapitulated in the clinic, especially when assessed in randomized phase III clinical trials.

2, 23 A similar, highly regulated pattern of development is recapitulated in many vertebrate species including mice, rats, and rabbits.

Clinically brain metastases can show highly variable permeability, and this is recapitulated in hematogenous metastases in animal models [ 36].

In summary, in addition to discovering many novel networks, highly cell-type-specific regulatory networks that recapitulated many known regulatory sub-networks were also revealed by co-association networks of TFs [25].

This suggests that IBC cells present a highly specific profile of essential genes that is not recapitulated by other breast cancer subtypes.