Sentence examples for highly protein from inspiring English sources

Bioavailability for sarolaner was calculated at >85% and the compound was highly protein bound (>99.9%).

Protein adsorption experiments on copolymer coated planar surfaces with surface plasmon resonance (SPR) spectroscopy reveal the ability of the tested thermoresponsive coatings to be switched between highly protein resistant and adsorptive states.

Results of the analyses of eprinomectin B1a described here showed that it is metabolically stable and highly protein bound (>99%), and thus likely to be, as with other species, excreted mainly as unchanged parent drug in the feces of cats.

Statins are highly protein bound, a fact that may well be important in the critically ill patient [32].

Apart from the metabolic interactions, highly protein bound drugs can displace warfarin from serum albumin and cause an increase in the INR.

Compounds of this class are relatively highly protein bound [39] and it is possible that they bind to the encapsulating collagen matrix leading to decreased efficacy.

Problems have been encountered in the detection of lipophilic and highly protein-bound substances.

The transport of highly protein-bound drugs such as paclitaxel and doxorubicin in a solid tumor is retarded by a high tumor cell density and enhanced by drug-induced apoptosis.

Accordingly, the delivery of a highly protein-bound drug to cells in a solid tumor is affected by its apoptotic effects and is therefore determined by the drug concentration and the treatment duration, i.e. treatment schedule.

While lipophilic drugs and highly protein-bound drugs (eg, voriconazole and fentanyl) are significantly sequestered in the circuit, hydrophilic drugs (eg, β-lactam antibiotics, glycopeptides) are significantly affected by hemodilution and other pathophysiologic changes that occur during ECMO.

In contrast, CRRT clearance for the highly protein-bound flucloxacillin is minimal [78, 79].