Exact(4)
As EM CD4 T cells are thought to derive from highly proliferated CD4 T cells and ICOS costimulation has been found to enhance proliferation of CD4 T cells [23], we hypothesized that ICOS costimulation might play a role in the development or homeostatic proliferation of EM CD4 T cells.
About 40% of the cancers were intermediate or highly proliferated.
In sharp contrast, B6 c-FLIPL Tg T cells highly proliferated in response to lower doses of anti-CD3 stimulation, although they displayed a similar sensitivity to apoptosis (Supplementary Figure S5b), in agreement with the previous reports 6, 19.
Previous studies had demonstrated that the endoplasmic reticulum in S. cerevisiae was highly proliferated when an excess of fatty acids was present in a dga1∆lro1∆are1∆are2∆ mutant grown on oleate [38].
Similar(56)
Bid et al. demonstrated that silencing endogenous ΔNp63α in highly proliferating tumorigenic OS cell lines reduced cell proliferation and colony formation.
In this HA antigen-independent environment, anti-CD40L again reduced the numbers of highly proliferating CD4+ T cells (Fig. 2A), whereas proliferation profiles of donor CD8+ T cells were not significantly different (Fig. 2B).
The highly proliferating tumor showed tuberous infiltration.
Argyrophilic nucleolar organizer regions (AgNOR) proteins are a set of argyrophilic nucleolar proteins that accumulate in highly proliferating cells, whereas their expression is very low in nonproliferating cells.
ERK1 and pERK1/2 were found to be expressed in a significantly higher proportion of cells with differentiated and highly proliferating epithelial components, as compared with those of nondifferentiated, quiescent epithelial rests.
Molecular studies showed that HypoARC significantly improves local relapse-free survival in patients with highly proliferating tumors or tumors overexpressing proteins linked to increased resistance to radiation-induced apoptosis (ie, c-erbB-2 and mutant p53).
This leads to the question of which cell type should be the cell source for tissue-engineering of ligament, the highly proliferating cells or the differentiated matrix producing cells.
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