Sentence examples for highly prognostic of from inspiring English sources

Moreover, the involvement of PHOX2B and its paralogue PHOX2A in NB pathogenesis seems to be also mediated by a mechanism of gene up-regulation [14], with abundance of PHOX2B transcript shown to be highly prognostic of poorer progression-free and overall survival [15], [16].

This could be highly clinically relevant as even in a triple negative marker group, CD151 is highly prognostic of both DSS and RFS.

Included in the resulting inventory are not only such familiar sets as "estrogen" and "erbb2/17q12", but additional sets highly prognostic of survival.

It is well documented that inflammation and a wound-like signature promotes breast cancer tumorigenesis and is highly prognostic of breast cancer survival [ 61- 63].

The Kaplan-Meier analysis of grouped Sirt1 expression (IRS ≤6, >6) was highly prognostic of poor overall survival for those patients with high Sirt1 expression with a mean postsurgical survival of 13.0 vs. 54.1 months (log-rank test: p = 0.002).

Based on the results of our study, the fact that the MRC score predicts severity and outcome of IPF, could be explained by the finding that the MRC score is related to major functional parameters of both maximal and submaximal exercise testing known to reflect ventilatory impairment, exercise limitation and extent of disease and found to be themselves highly prognostic of survival in IPF.

To date, several methylated genes have been found to be highly prognostic for specific cancers, including those of the prostate [ 31], breast [ 32] and lung [ 33].

Consequently, Cox proportional hazard regression analyses revealed categorical CTC-counts highly prognostic for OS with a HR of 3.8 (95 % CI 1.4-10.3) at baseline and a HR of 4.5 (95 % CI 1.9-10.8) at q1 and 5.8 (95 % CI 2.2-15.1) at q4.

The SPC gene set includes 259 unique named genes represented by 340 transcripts that are highly prognostic for death due to ccRCC independent of clinical and pathological features.

It has been known that plasma ADM levels strongly increase with the severity of sepsis, severe sepsis, and septic shock, and that elevated levels are highly prognostic for fatal outcome [24 26].

Moreover, this signature was highly prognostic for poor survival.