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Given their excellent antioxidant and anti-inflammatory activities, we anticipate that HPOX nanoparticles are highly potent for the treatment of oxidative damage-related diseases, such as asthma.
Interestingly, these dimers 6a d are significantly more cytotoxic than 4 in a number of human cancer cell lines, in particular, compound 6c is highly potent for almost all the nine human cancer cell lines.
Compound 66 was highly potent for PDE10A (IC50 = 1.4 nM), demonstrated high selectivity (>200×) for the other PDEs, and was efficacious in animal models of psychoses; reversal of MK-801 induced hyperactivity (MED = 0.1 mg/kg) and conditioned avoidance responding (CAR; ID50 = 0.2 mg/kg).
EPZ-5676 was highly potent for DOT1L with a Morrison Ki of 0.08 ± 0.03 nM.
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These results indicate that GMP scores of cancerous tissue combined with UGT1A1 genotyping of blood samples may serve as highly potent markers for predicting the efficacy of NAC for individual SCC patients.
A detailed understanding of the mechanisms of enzyme regulation is essential for the design of highly specific and highly potent modulators for the treatment of these patients with minimal side effects.
Low-dose ARB treatment might be considered as a neuroprotective treatment after cerebral infarction, and fimasartan is a good candidate for low-dose treatment because it has highly potent affinity for AT1 compared to other ARBs.
Ergotamines are highly potent drugs for treating migraine.
Designing highly potent shRNAs for long-term gene silencing has been a tougher problem.
Nostoc ellipsosporum is a highly potent cyanobacterium for production of pharmaceutically important chemicals.
It has been well documented that DNA vaccination is a highly potent strategy for inducing both prophylactic and therapeutic responses [25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com