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Recently, a novel class of highly potent and specific MDM2 antagonists, the Nutlins, was identified.
These analogues are highly potent and selective inhibitors against fXa.
However, recently, research is focusing on compounds containing highly potent and specific anti-retrovirals.
Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36.
The resultant QSAR model will be useful for designing highly potent and selective PK-C ligands.
Herein, we report two highly potent and selective small molecule inhibitors of human 11β-HSD1.
Escitalopram is highly potent and highly selective serotonin re-uptake inhibitor.
A range of highly potent and selective inhibitors is now available for cellular studies.
Rationale: Flesinoxan is a highly potent and selective 5-HT1A agonist.
The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported.
A highly potent and orally bioavailable compound (compound 9) was identified and selected for development.
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