Once you get past 100 customers this gets extremely onerous.
This results in highly duplicative and onerous procedures which are mainly administrative and have little (if no) positive impact on quality, safety and efficacy.
Second, they could delay the launch of a highly innovative drug by demanding onerous or unnecessary trials and thereby deny many needy patients a new therapy.Proper regulation requires balancing these two risks, but the pitch may be queered by bureaucratic self-interest.
But that estimate was based on a highly debatable assumption -- that Congress would adhere to onerous spending caps it set in 1997 to achieve a balanced budget.
However, the severity of the contingencies that SIPS are designed to protect against and the highly intrusive nature of many of the actions available to them mean that SIPS face onerous requirements in terms of both dependability and security [56].
They also described prompting and cueing strategies to be highly idiosyncratic, intuitive, and tacit; explicating and "programming" this information into the system was perceived as onerous.
At a news conference in Islamabad today, Mr. Aziz was sober about what he called "the more onerous phase" of the economic plans, one that will again ask people to do something highly unpopular, even radical in Pakistan: "I appeal to all the citizens of Pakistan to diligently fulfill their tax obligations," he said.
They concluded that poor farmers, particularly in places with poor but highly fluctuating yields, find it harder to meet the expenses of Bt. cotton farming and, thereby, incur onerous debt and likely suicide (Gutierrez et al., 2015).
It should be illegal to advertise highly fattening food as "fat free". People have the right to be unhealthy, but we should make that choice more onerous and expensive by imposing taxes on soda and junk food.
This could account (in part) for some of the onerous and often costly procedures required when applying conventional restoration approaches (usually reserved for less assertive disturbance impacts) to highly disturbed post-mining environments (Gardner and Bell 2007; Koch 2007).
