Sentence examples for highly mutated upon from inspiring English sources

This resulted in the identification of 20 genes that are consistently and highly mutated upon aging.

Although not typically mutated in pancreatic cancer, Pten was highly mutated in two recent screens for gene mutations that accelerate KrasG12D-driven pancreatic tumorigenesis.

DCLK1 is among the 15 most common putative driver genes for gastric cancers and is highly mutated across various other human cancers.

The PI3KCA gene (coding for the p110α catalytic subunit of PI3K) have been described to be highly mutated in human tumors [2], [7].

Three of the five tumors had a T2/OncZ insertion in one gene (CBL, TSHR, or SMARCB1) known to be highly mutated in human cancers [46].

N-ras is highly associated with skin and hematological cancers, while K-ras is highly mutated in pancreatic and intestinal cancers (Prior et al., 2012).

These properties include expected instances where a highly mutated gene contained a highly mutated domain, but also unexpected instances where a shared domain is highly mutated, but the individual genes are not, or even where after the removal of mutations from highly mutated genes, some genes still contain mutations within the shared domain.

These genes are not selected by our method because they are mainly mutated in the highly mutated samples and the scores of the mutations are not high.

Figure 2 shows that the mutations in these genes are clustered in the highly mutated samples except one in PDGFRA.

Nested PCR primers were designed to align to sequences flanking the V(D J coding region to enable amplification of highly mutated antibody sequences.

Computational methods that exploit structural and evolutionary information are being used to design highly mutated yet still natively folded chimeric proteins and protein libraries.