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TERT rs2736100 polymorphism may contribute directly to disease predisposition by modifying the function of TERT or is in highly linkage disequilibrium (LD) with other nearby biologically plausible and disease-causing mutations.
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Consistently, agriculture, food, and rubber industry have been specified as key sectors promising for export as they are highly linkage-oriented, able to induce high multiplier on income, and possess high labor contents, while garment is unlikely to contribute profit due to the lack of inter-industrial linkages (Chhuor 2016).
This region showed a highly significant linkage in a fine scale linkage study by Brasch-Andersen et al who also included the sample we have included as sample C. A possible explanation may be that the subjects in this study almost all had asthma as well as AR.
We describe an exact-match based, highly efficient linkage scheme suitable for large scale linkage of hospital records.
Several SNPs showed highly significant linkage and association with resistance to IPN, and population linkage-disequilibrium-based SNP tests for resistance were identified.
Results showed reliable evidence of highly suggestive linkage on chromosome 5 for spine (LOD score = 3.0) and suggestive linkage for femur (LOD score = 2.19) in the regions of 105cM and 155cM respectively.
A highly stringent linkage analysis method was conducted, using the double pseudo-testcross strategy [ 134], as in other linkage analyses of hop [ 14- 17].
Highly significant linkage disequilibrium was shown among exons 12 C1216T, 21 G2677T and 26 C3435T, which could account for most of the haplotypes (combinations of SNPs) seen in ABCB1 [13 15].
This analysis identified a highly significant linkage associated with fungal burden in the kidney on chromosome 11 (LOD = 4.59, P<0.01) and chromosome 8 (LO D= 3.95, P<0.05) (Figure 7A and 7B).
Interestingly, two of the genes in this network have previously been associated with schizophrenia as deregulated in postmortem brains (CCND2 [39]) or positioned under a highly significant linkage peak (PTPN1[40]).
Two replicate samples of genomic DNA each extracted from 10 fliesies displaying heart failure in the testcross of NC1 by yw resulted in a highly significant linkage peak at the identical position on the right arm of chromosome 3 (Figure 3), consistent with the presence of a dominant susceptibility locus centered on the interval 97C in the NC1 line.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com