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Given, however, the increasing evidences indicating that cellular components do not function in isolation but form a complex interwoven network, it is still unclear to what extent the conclusions drawn from the elementary circuit analogy hold for systems that are highly interacting with surrounding environments.
The mass transport of water (highly interacting with CNC) and anisole (interacting only with designed CNC surfaces) exhibited non-Fickian, Case II behaviour.
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The IGF-1 pathway highly interacts with the p53 pathway and both pathways constitutes important components involved in longevity [ 27- 29].
Since proteins in complexes highly interact with one another, graph clustering has also been used to discover protein complexes in PPI networks [ 55].
The graph clustering is based on the assumption that a group of functionally related nodes are likely to highly interact with each other while being more separate from the rest of the network [ 15].
It is noted that the number of "DOWN" DEGs identified is larger than "UP" DEGs in both of early- and late-stages, in which the ratio is about 2 to 1. Genes which do not highly interact with other genes are assumed to be less important and consequently such genes were removed before the subsequent analysis.
First, given that protein members of a complex core highly interact with each other, it should be dense.
A connectivity distribution analysis allowed us to identify those proteins that highly interact with others, defined as the hubs of the expanded network.
They also found that highly charged polymers interacting with the glass nanopipette surface modulated the rectification property of the nanopipette electrode.
It also indicates that the alkyl ammonium group is highly mobile in interacting with Glu55, Glu64, and Glu164.
Among the 11 nodes in the PPIN, HC-Pro is the most highly connected component, interacting with all other nodes.
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