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However, sensitivity analyses showed that permutations of mitigation strategies that included adults were effective at reducing infections in the model population, even for more highly infective 1918-like viral strains or with removal of enhanced children/teenagers' role in transmission (10 ).
The influenza A virus is a highly infective agent that causes acute pulmonary diseases.
Mosquitoes fed on blood spiked with DN-2 resulted in 5 lower levelslevels of viral RNA compared to those fed with a similar amount of the highly infective and transmissible Paraiba strain38 (Supplementary Fig. 5).
A further consideration is that of oocyst viability assessment, particularly significant due to the environmental longevity and highly infective nature of this pathogen, with a single viable oocyst capable of causing disease.
Furthermore, BS are highly infective against a number of insect pests and have a lower LD50 when compared to AC or SCS (Hegedus et al. [1992]).
Next comes secondary sores, often on the tongue and pulsating with highly infective bacteria, and then rashes, warts, and madness.
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In our interpretation few contaminating PSNEG parasites (Fig. S1), generates highly infected macrophages which are exquisitely inactivated by the high number of PSPOS forms present in the infective inoculum.
Moreover, it is a highly pathogenic organism, requiring medical attention within 24 48 h of initial exposure, and infective doses have been estimated to be very low (e.g., 8,000 to 10,000 spores inhaled) [ 3].
As originally demonstrated under in vitro culture conditions, and here confirmed during development in P. papatasi, the HASPB and SHERP proteins are highly upregulated in infective metacyclic stages, with SHERP also showing low-level expression in the preceding short promastigote stage in the vector.
This difference in substrate specificities and the essentiality of NAD+-dependent ligase for bacterial survival make NAD+-dependent ligase a good target for designing highly specific anti-infectives.
By using reverse genetics, we systemically created 127 reassortant viruses between a duck isolate of H5N1, specifically retaining its hemagglutinin (HA) gene throughout, and a highly transmissible, human-infective H1N1 virus.
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