Our results highly indicate that QDs-labeled MSCs can target in vivo pancreatic tissues of diabetic rats, and decrease the blood glucose levels, and then, in vivo transplanted MSCs may own clinical therapeutic prospect to diabetic patients.
Several studies highly indicate that the unique immunomodulatory effects of MSCs seemed to be closely associated with decreasing hyperglycemia.
In test group HAI-178-FMNPs, the tumor tissues grew slowest, which highly indicate that the prepared HAI-178-FMNPs have a therapeutic function for gastric cancer in vivo.
In our study, we confirmed that α-subunit of ATP synthase also exhibited over-expression in 94.7% of the gastric cancer specimens, which highly indicate that the α-subunit of ATP synthase may be a potential target for gastric cancer diagnosis and therapy.
The presence of ALDHhighCD44+ subpopulations in the ALDH-sorted fractions highly indicates that in addition to ALDH, CD44 may also contribute to cisplatin resistance.
Despite the differences in calculation of both composite scores, they do correlate highly, indicating that they do represent similar constructs [ 58, 59].
These results highly indicate that ALDH 1A2, ALDH1A3 and CD44 confer resistance to cisplatin + DEAB; hence, the cells bearing these markers may partially account for the re-appearance of spheres after the drug treatment.
Further on, this approach resulted in significant improvements in terms of local control, freedom from distant metastases, disease-free and overall survival compared to a historical control group treated without chemotherapy, highly indicating that a neoadjuvant approach might be beneficial.
Moreover, given the adequate power, the p-values were highly significant which indicated that our estimates were relatively accurate.
