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Similarity (kernel) matrices have the advantage of being directly comparable even when computed from highly heterogeneous data.
Public repositories, however, contain thousands of independent studies with highly heterogeneous data from different labs, platforms, and organisms.
A number of factors must be considered when performing a comparative analysis of highly heterogeneous data from different sources, platforms, and technologies.
This learning method was chosen because of its transparency and ease of integration of highly heterogeneous data.
These highly heterogeneous data contributed not only to inferring stronger relationships through the accumulation of evidence, but also providing broader coverage than any single data source.
Health information exchanges (HIE's), with highly heterogeneous data, are becoming increasingly important sources of integrated clinical data supporting many healthcare tasks and health-related research.
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The superior performance of BEST in these synthetic datasets suggested that our algorithm worked well in the context of highly heterogeneous microarray data and was robust against moderately distorted data and sporadic outliers.
These limitations, however, are balanced by strengths: the unusual, highly heterogeneous population, data extraction from computerised records augmented with manual abstraction for quality control, and a consistent, single-institution approach to pathological diagnosis and patient care.
But, unlike the data gathered by Google, WeChat and Ali Baba, the big biological data is highly heterogeneous; even within the data, there exist intrinsic structures determined by various biological principles and experiment designs.
Since MS is a highly heterogeneous disease, diverging data may simply reflect different MS forms.
As the disease is so highly heterogeneous, pooling of sample data was not feasible and thus by its very nature, this project required a large international collaboration between clinicians and molecular geneticists (the IGOLD project; http://goldstudy.cimr.cam.ac.uk/).ac.uk/
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