In such cases, measurements of linkage either cannot be made or become highly inaccurate when extrapolated over the time between sample points.
Extrapolating highly variable estimates produced using problematic methods in time and space creates extreme uncertainty and low confidence in these scaled estimates.
While it would be highly speculative to extrapolate Wheels Up's surge in business to his leading competitors, there is no question that some other operators also are experiencing robust demand for their services as well and facing a common challenge: managing growth.
This latter is also still poorly defined and extrapolated from the highly documented and referenced experience with destructive articular infections of the hip and knee [9, 18, 20, 21, 22].
This process was highly context-specific and cannot be extrapolated to other regions.
Temperature dependence was then evaluated using equations 20 and 21 (Figure 10) and extrapolated to 175°C, because the highly linear and limited data set at this temperature did not allow contributions of homogeneous and defect-assisted nucleation to be constrained.
While this result is of interest to large, highly ventilated corporate offices, it cannot be extrapolated to buildings with lower rates of outdoor air supply.
The modeling of complex concentration response functions to only few cases of disease may lead to highly speculative results, especially when the models are extrapolated (Kay et al. 2004).
Therefore, the data from studies on F. novicida or LVS cannot simply be extrapolated and assumed to be relevant for highly virulent strains.
However, the sample was drawn through a drug distribution program with prescreening requirements that selected for highly motivated patients, so whether the findings can be extrapolated to other populations remains unclear.
