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This makes the choice of cytotoxin particularly important, as it is required to be highly efficacious at very low concentrations.
Praziquantel treatment was highly efficacious at three weeks after treatment when judged by egg reduction rate (95.3%) and cure rate of heavy infections (94.1%).
Based on this theory and prior research, we hypothesized that OSGs that maximize opportunities for providing help to others would be highly efficacious at reducing distress symptoms.
Among patients with diabetes, currently used drug eluting stents are highly efficacious at reducing the risk of target vessel revascularisation/target lesion revascularisation without compromising safety outcomes, including very late stent thrombosis, compared with bare metal stents.
In patients with diabetes all drug eluting stents are highly efficacious at reducing the risk of target vessel revascularisation without increases in any adverse safety outcomes, including very late stent thrombosis, when compared with bare metal stents.
It shows that, given the ability of very low P. falciparum gametocyte densities to establish infection in A. gambiae, transmission-reducing interventions will need to be highly efficacious at reducing gametocyte density in order to halt human to mosquito transmission.
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This is the case for all transmission settings and for all events averted, except in the case of highly efficacious BSV combined with MSTBV at very high transmission.
For highly efficacious BSV, we observe effects on transmission, particularly at high transmission settings (Figure 1b, d, f).
As a result, patients may receive traditional systemic drugs or expensive biological agents only because the infrastructure to deliver a highly efficacious and cheaper treatment with ultraviolet B light at home is lacking.
Dietary celecoxib at 1,200 mg/kg diet was highly efficacious in the prevention of hormonally responsive mammary carcinomas in intact rats, decreasing tumor multiplicity by 56% (P < 0.0001) and by 74% (P = 0.0002) in two independent experiments.
For the primary endpoint of this trial, parasitological cure at Day 28 (PP population), CDA was highly efficacious (94%).
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