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However, a significant obstacle to effective model-based studies comes from the fact that it is highly difficult to achieve the values of model parameters.
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The ability to relate detailed genetic information to management and outcome in large case series is highly desirable but difficult to achieve.
Even modest upgrades and changes in equipment, he maintains, are highly complex, making it difficult to achieve the required safety standards without extensive domestic expertise in this area.
The primary outcome is targeted vision function (TVF), which refers to specific vision-dependent functional goals that subjects highly value but find difficult to achieve.
It may be difficult to achieve highly confidential mental health care at primary care clinics as currently organized.
Normally-open and normally-closed valves are difficult to achieve and highly demanded in centrifugal microfluidic systems.
Thus, operative techniques must be highly accurate because hemostasis can be difficult to achieve.
Overall, a joined up approach is no guarantee of success – it is difficult to achieve and highly variable in its outcomes [ 20, 34].
This colour, known as rouge clair, was the most difficult to achieve technically, and highly prized for this and the brilliance of the colour when it was done successfully.
Children and young people's preferences for highly individualised, collaborative, relationship-based, care are difficult to achieve.
The first usually introduces a compromise between ultrastructure and labeling efficiency, whereas the second is difficult to achieve on thick or highly aqueous samples.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com