The degree of PSG9 expression in the tumour samples appears to be related to differentiation, with highly differentiated cells expressing the highest levels.
The differences in PD-1 expression on A2-BMLF-1 and A2-BRLF-1 CD8+ T cells, despite highly similar differentiation phenotypes, suggests a dissociation between signaling pathways that determine differentiation states and PD-1 expression.
During endochondral ossification, mesenchymal stem cells undergo a highly organized differentiation program during which they condense and differentiate into chondrocytes, forming the template for bone formation (Kronenberg, 2003; Yoon and Lyons, 2004).
Similarly, other graphene-based topographical features (grids) presented highly accelerated differentiation that was also attributed to their ability to adsorb chemical inducers [23].
Therefore, the highly accelerated differentiation on the rGONR grid was assigned to both its excellent capability in adsorption of the chemical inducers and physical stresses induced by the surface topographic features of the nanogrids.
The versatility of signaling receptors could enable ES cells to transform diverse stimulus into highly variable differentiation behaviors.
Notably, the bbee mice showed a highly defective differentiation of neutrophils with large and in part indented nuclei (Figure 2), representing a potential block at the myelocytes to metamyelocytes stage of differentiation.
In conclusion, our results reveal both imprinted and highly flexible differentiation and effector programs of neonatal NKT cells, whose flexibility progressively diminish in adult NKT cells as they acquire a more differentiated phenotype.
Decreased genes in "rapid" progressors included Smad6, an inhibitor of TGF-beta Smad-mediated signal transduction, and the receptor for advanced glycation end-products which is a highly selective differentiation marker of alveolar epithelial type I cells [38].
