Sentence examples for highly destabilizing from inspiring English sources

Economic reform and opening threatens to be highly destabilizing.

Venezuela's heavy reliance on its oil industry makes any disruption of PDVSA operations highly destabilizing to the government.

The influx of many more Palestinians and Iraqis during an unpopular war could be highly destabilizing for the monarchy.

Professor Dupont, who is also a foreign policy adviser to Mr. Ramos-Horta, said the attacks were highly destabilizing.

We find that Arrowhead increases the exposure to systemic risk even more during tail-risk events, which can potentially lead to a highly destabilizing market situation.

From the early 1990s this paradigm was shaken by critiques which argued that federalism and autonomy more generally were highly destabilizing in ethnically divided states where the federal administrative architecture and boundaries were drawn to reflect ethnic divisions.

However, a highly destabilized cysteine-free mutant of SPEA did not provide effective immunity, nor did an irreversibly denatured version of an otherwise effective mutant protein.

Further, we have analyzed the molecular interactions of P-gp substrates/inhibitors during the P-gp translocation to find out how stable binding interactions of a compound at drug-binding site(s) in open conformation, becomes highly destabilized in closed conformation.

Specifically, we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase (MODC) to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein, designated as dBiFP, and show that the dBiFP protein is highly destabilized, compared with the commonly-used eGFP protein.

The amount of amyloid formation is correlated with the effect of the mutations on stability: A4V, one of the most highly destabilized ALS mutants, forms amyloid in very high yield, with less amyloid formed from the moderately destabilized G93A, and G85R, the least destabilized of the three mutants, forming virtually no amyloid.

In a previous work, we have generated a transgenic model for TTR-associated amyloidosis in the fly Drosophila melanogaster by overexpressing either normal TTR (TTRwt), the clinically relevant mutant TTRL55P, or the highly destabilized engineered mutant TTR-A (TTRV14N/V16E; [20]), all in secreted form and thus detectable in hemolymph [21].