"There's no question that it is highly, highly deleterious to butterflies and other arthropods, even mammals in high enough doses".
Excessive Fe uptake is highly deleterious, as it catalyzes the generation of reactive oxygen species.
The convergence of these observations suggests that vaccines designed to focus immune responses narrowly against regions of HIV susceptible to highly deleterious mutations might prove effective in controlling viral replication to levels that slow disease progression and reduce transmission.
Mobile elements with CRISPR containing spacers matching the host chromosome could have highly deleterious effects.
We may wish to consider only those mutations that are nonsynonymous, and in particular those that are highly deleterious.
This is expected in populations of highly variable RNA viruses and implies that non-synonymous substitutions can be highly deleterious [68], [69].
Because these changes are highly deleterious in their mitochondrial counterpart and cannot persist in the mitochondrial genome, they must have been gained in the nuclear genome.
However, in patients younger than 3 years of age, radiation is often avoided if possible due to the highly deleterious effects seen on the developing brain [3].
From the analysis expression levels of the variant chimeras, we observed that the 5' segment of A11 appeared highly deleterious for expression (Table 1).
It indicates that the ablation of OD is highly deleterious to the cell even when the activity was reduced by a mere 8%.
In addition, distribution of fitness effects in a non-stationary population suggested that at least 30% of the non-synonymous or 16% of all mutations in human nuclear genes are highly deleterious [49].
