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For several decades, the phenomenon of membrane component segregation into microdomains has been a well-known and highly debated subject, and varying concepts including the raft hypothesis, the fence-and-picket model, hydrophobic-mismatch, and specific protein protein interactions have been offered as explanations.
Introduction End-of-life is a highly debated subject.
The structural mechanism of T cell recognition is a highly debated subject in the immunological literature and a consensus view of the promiscuous peptide recognition has not yet been reached (see e.g., [5]).
Certain ideas can be borrowed directly from another well studied but still highly debated subject, the evolution of genome size.
The exact nature of those 'responsibilities', however, was left somewhat vague and over time has been, and would continue to be, a highly debated subject.
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This topic remains a highly debated issue today.
Reconnection at Saturn is a highly debated topic.
Dinosaur physiology remains a debated subject.
It is a hotly debated subject.
However, the true reasons behind drug failure during development remain a highly debated and poorly understood issue for many, primarily due to the lack of detailed and up-to-date data on the subject.
The issue is highly debated [ 76, 77].
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