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CNE1 spans a human/Fugu conserved region of exceptionally extended length, 935 bp, and embedded within it a highly constraint interval of 125 bp almost 100% conserved down to chick, while depicting a 92% conservation in human/fish comparison.
But we did not observe this homologous sequence using the all three methods: the genomic Southern analysis, the BLAST analysis of the sequenced genomes of maize, and the PCR amplification, in contrast to an expectation that can be made given the highly constraint detected from this gene.
Although laboratory measures have the advantage of providing an objective, quantifiable measure of hedonic capacity, the highly constraint laboratory-based environment has its limitations to everyday life situation which is more complex and full of distracters.
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Other examples of genes under highly functional constraint on gene duplication are the genes encoding the LEAFY transcription factor, one of the few transcription factors found as single-copy in all plant species, with the exception of gymnosperms (Baum et al. 2005).
Consequently, even highly stringent constraints on gene order in the vector world are apt to be less restrictive than the constraints of quaternary structure in the protein world.
The robustness and accuracy of the method are examined by solving design problems with highly nonlinear constraints and comparing with the results of common RBDO methods.
Optimum design of real world steel space frames under design code provisions is a complicated optimization problem due to the presence of large numbers of highly nonlinear constraints and discrete design variables.
For reliability-based design optimization (RBDO) of practical structural/mechanical problems under highly nonlinear constraints, it is an important characteristic of the performance measure approach (PMA) to show robustness and high convergence rate.
Challenges include highly visible constraints on number, distribution, and training of service delivery staff, especially in countries hardest hit by the HIV-AIDS epidemic [ 2- 4].
The primary goal of the present study was to test the effect of word skipping on fixation position under highly controlled constraints in a single-saccade paradigm.
UMMI finds several highly reliable constraints at each time point (Additional file 1, Table S1) that pass a reliability threshold (frequency of occurrence in the learned models) of 0.1.
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