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The enrichment and separation of phosphopeptides from mixed biological samples is a technologically very significance, but highly challenging work.
The concern is that after 12 straight days of highly challenging work, exhaustion is putting patients in danger.
A university hospital is a complex, continuously changing and highly challenging work environment.
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Such a low rate of loss coupled with variability of measurement makes studies evaluating factors that might affect cartilage loss highly challenging and also makes drug development work difficult.
Needless to say, this issue is highly challenging, in both theory ad practice, and thus it is left for future work.
It's challenging work".
This was brave and challenging work.
It is a challenging work.
"Playing four Test matches in India is a highly challenging activity.
"Sam was a highly challenging child," says his former headteacher, Greg Walter.
Dance Theater Workshop is associated with experimental, challenging work.
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