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Modelling protein flexibility is still a highly challenging objective in various fields of computer aided drug design.
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These objective functions are of- ten in conflict, making them highly challenging in terms of determining optimal solutions and analysing solutions obtained.
"Playing four Test matches in India is a highly challenging activity.
"Sam was a highly challenging child," says his former headteacher, Greg Walter.
"Lincoln," however, accomplishes a far more challenging objective: its speculations actually advance the way historians will consider this subject.
"This has created a highly challenging and sensitive situation, which has slowed the possible rate of evacuations".
Running a marathon or climbing a mountain is a straightforward, if not challenging, objective.
It's a new, highly challenging difficulty mode exclusive to the PlayStation 3 version of BioShock.
Its prediction from chemical structure remains a highly challenging task for quantitative structure activity relationship studies.
Providing a networked and personalized VBL experience is a highly challenging task.
Optimizing the performance of wireless networks for emerging network applications is a highly challenging issue.
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