Sentence examples for highly challenging difficulty from inspiring English sources

It's a new, highly challenging difficulty mode exclusive to the PlayStation 3 version of BioShock.

With appropriate treatment in rehabilitation even individuals with highly challenging difficulties can move on to successful and stable community living [ 4, 5].

What is unique about Nepal is the extreme diversity of these, coupled with the equally extreme and highly challenging geoclimatic variation, with the attendant difficulties of transport and access.

However, production of biofuel from inedible and cheap feedstock is highly challenging due to the slower utilization of biomass-driven sugars, arising from complex assimilation pathway, difficulties in amplification of biosynthetic pathways for heterologous metabolite, and redox imbalance caused by consuming intracellular reducing power to produce quite reduced biofuel.

Both mentor and acolyte were largely unscathed by Cubism and its challenging difficulty.

"Playing four Test matches in India is a highly challenging activity.

"Sam was a highly challenging child," says his former headteacher, Greg Walter.

"This has created a highly challenging and sensitive situation, which has slowed the possible rate of evacuations".

Oil/water well casing damage is a challenging difficulty to oil reservoir engineering.

Accumulation of nitrite intermediate in autohydrogenotrophic denitrification process has been a challenging difficulty to tackle.

Its prediction from chemical structure remains a highly challenging task for quantitative structure activity relationship studies.