highly bound

USAGE SUMMARY

The phrase "highly bound" is correct and usable in written English.
It can be used to describe something that is tightly or strongly connected or restricted, often in a technical or scientific context. Example: "The molecules in this compound are highly bound, resulting in a stable structure that is resistant to changes in temperature."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

A single binding site was observed in the BSA rivaroxaban complex and the binding constants indicated that their binding is quite strong to be highly bound in plasma.

Chemistry Central Journal

As said before, both are highly bound to albumin, i.e. more than 90%, and distribution of the two drugs in the body after parenteral administration is similar.

Annals of Intensive Care

Considering that oxa- and cloxacillin are highly bound to albumin (up to 90%) [24], we assumed that the unbound fraction increased in hypoproteinemic patients.

Annals of Intensive Care

Enhanced elimination also can be due to a hypoalbuminemia-related reduction in protein binding, particular for highly bound antibiotics, such as flucloxacillin and ceftriaxone [27, 28, 32].

Annals of Intensive Care

Finally, the PPB prediction denotes that all the designed molecules have binding ≤90%% clearly revealing that the molecules have good bioavailability and are not likely to be highly bound to carrier proteins in the blood [25].

Chemistry Central Journal

Considering that oxa- and cloxacillin are highly bound to albumin and that their unbound fraction i.e. the available fraction for antibiotic efficacy in healthy patients is known to be 10%, we defined a target range of total antibiotic concentration of 20 50 mg/L to reach the 100% T > MIC.

Annals of Intensive Care

We focus on drugs that are highly bound as this will restrict their potential to move freely into the skin but which are lipophilic so that, in the unbound form, they would demonstrate an affinity to the outer layers of the skin.

Mathematical Biosciences

Ritonavir but also lopinavir are highly bound in plasma to albumin and α1-acid glycoprotein [32].

Plosone

It is expected that lopinavir and ritonavir are also highly bound to proteins within cells.

Plosone

While specific immunoglobulins and complement may enhance antibacterial activity of β-lactams, albumin may limitate its activity in highly bound agents.

Plosone

Although it may be argued that serum concentrations do not resemble nasopharynx concentrations, free-drug concentrations were used as an approximation despite the fact that protein binding of the highly bound cephalosporin may not highly influence bacterial killing [38].

Plosone

Expert writing Tips

Best practice

When describing the properties of a drug or chemical, use "highly bound" to clearly indicate its affinity for binding to proteins or other substances. This is especially important in scientific writing.

Common error

While "highly bound" indicates a strong affinity, avoid using it hyperbolically. Quantify the degree of binding whenever possible (e.g., "95% bound to albumin") to provide more precise and credible information.

Linguistic Context

The phrase "highly bound" primarily functions as an adjectival modifier, describing the extent to which something is connected or attached. As seen in Ludwig, this phrase is commonly used in scientific and technical contexts to specify the degree of binding.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, "highly bound" is a precise and informative phrase predominantly used in scientific and technical domains to describe the extent of binding or attachment. As confirmed by Ludwig, its grammatical correctness and frequent usage in scholarly articles make it a valuable term for detailed explanations of chemical and biological processes. While synonyms exist, the specificity of "highly bound" often makes it the preferred choice in formal writing, particularly when discussing pharmacokinetics, chemical interactions, or material properties.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

tightly connected

Emphasizes the closeness of the connection between elements.

strongly attached

Highlights the strength of the bond or attachment.

firmly secured

Focuses on the security and stability of the binding.

closely linked

Indicates a close relationship or association.

intimately connected

Suggests a deep and significant connection.

tenaciously held

Emphasizes the persistence and strength of the binding.

strongly associated

Indicates a notable correlation or relationship.

deeply intertwined

Suggests a complex and inseparable connection.

heavily reliant

Focuses on the dependence or reliance on something.

inseparably linked

Highlights the inability to separate the connected elements.

FAQs

How is "highly bound" typically used in scientific writing?

In scientific contexts, "highly bound" is frequently used to describe the degree to which a substance, such as a drug or chemical, binds to proteins or other molecules. It's important for understanding pharmacokinetics and potential interactions.

What are some synonyms for "highly bound"?

Alternatives to "highly bound" include "tightly connected", "strongly attached", or "firmly secured", depending on the specific nuance you want to convey.

In what contexts is it most appropriate to use the phrase "highly bound"?

The phrase "highly bound" is most appropriate in technical or scientific contexts where describing the degree of binding or association is crucial. It is less common in informal or general writing.

How does protein binding affect the efficacy of a drug described as "highly bound"?

When a drug is described as "highly bound" to proteins, it means that a significant portion of the drug in the bloodstream is attached to proteins. This can affect its distribution, metabolism, and excretion, potentially reducing the amount of free drug available to exert its therapeutic effect.