Sentence examples for highly aggravated from inspiring English sources

Such problem is highly aggravated when it is necessary to determine the drug especially in pharmaceutical preparations.

The effects of strong binding of latent gelatinases to CI reduced by MMP activation were observed to be highly aggravated using this optimized buffer.

It is extremely aggravating for the cat.

LY2878735 PK appear to be highly variable, further aggravating the narrow concentration-based margin of safety.

In a recent study, it was shown that disease signs aggravated after infection with a highly virulent (HV) strain when pigs had been previously inoculated with a low virulent (LV) strain [ 9].

The challenges of accurate gene prediction and enumeration are further aggravated in large genomes that contain highly repetitive transposable elements (TEs).

This is further aggravated by exponentially growing costs resulting from highly priced drugs, increasing patient numbers and long-term disease chronicity.

This issue is likely aggravated when the organisms under consideration are highly dispersive, and thus likely to make biogeographic leaps that might seem extremely unlikely a priori.

To our knowledge, so far only one experimental study explored the effects of a brief, highly aggressive ventilation strategy in old rats and found aggravated lung injury in this population compared to young adult animals [ 21].

Moreover, the decrease in SIRT1 activity could not deacetylase its downstream targets such as p53 and NF- κB, which were highly activated by acetylation after cisplatin exposure, and thereby aggravated cisplatin-mediated ototoxicity through inflammation and apoptosis.

Terrestrial chelonians of arid regions are frequently faced with highly variable food quality and/or quantity and these problems could be aggravated in overgrazing areas.