Sentence examples for highly activating from inspiring English sources

First, the expression of FGFR3 harboring the highly activating TD-associated K650M or K650E mutations leads to activatory STAT1 Y701) phosphorylation in cells.

These highly activating groups especially enable the efficient introduction of [F]fluoride into aromatic rings to label small F-intermediates for build-up syntheses.

Both of the tumour models harboured highly activating oncogenic BRAF mutations leading to dependency on MEK-ERK1/2 signalling for survival and increased sensitivity to MEK1/2 signalling inhibition (Solit et al, 2006; Davies et al, 2007).

Spontaneous mTORC1 activity would suggest that AMPK is insufficiently activated in SLE T cells, which is unexpected under conditions of highly activated mitochondrial activity and ROS release.

On the other hand, the enzyme was highly activated by its activators NH4+, AMP and F2,6P [33].

Granulomatous lesions contain highly activated DCs, which have been implicated in promoting activation of vasculitic T cells [ 2].

GDH is readily adsorbed on highly activated anionic exchangers (HAAE), but hardly adsorbed on lowly activated supports (LAAE) or on highly activated epoxy supports.

The mitogen-activated protein kinase (MAPK) kinase (MEK) pathway is highly activated in many cancers including melanoma.

The highly activated CD8+ cells appear to be more susceptible to activation-induced cell death.

Paradoxically, CD14 deficiency is associated with greater bacterial burden despite the presence of highly activated neutrophils and macrophages and elevated levels of cytokines with potent antimicrobial activities.

The activation of MAPKs induces the production of proinflammatory cytokines and is highly activated in allergic reactions, including dermatitis [ 25].