Leaf compartments and roots displayed higher Al, Mo, Ni and Se annual mean concentrations than rhizomes, B was highly accumulated in blades and Cr in sheaths; As, Ba, Sr and Tl contents did not significantly vary among plant compartments.
In RS, H3K4me3, Kcr, and RNAPII were highly accumulated around the TSS, and Akap4 was robustly expressed.
At the PS active gene synaptonemal complex protein 3 (Sycp3), active modifications such as H3K4me3, H4K8ac, H4K16ac, and Kcr were highly accumulated at the TSS, and H3K4me2 exhibited a broader peak of enrichment near the TSS (Fig. 4a).
In biodistribution experiments of normal mice, Ga-DOTA(Asp 8, Ga-DOTA(Asp 11, and Ga-DOTA(Asp 14 selectively and highly accumulated in bone (10.5 ± 1.5, 15.1 ± 2.6, and 12.8 ± 1.7% ID/g, resp).
After target plot-based screening, 22 interactions involving 16 target genes and six sRNAs highly accumulated in the root tips, and 171 interactions involving 29 genes and 27 sRNAs (including osa-miR528-5p osa-miR528-5p osa-miR528-5ple roots passed thighlyidabundantddinional file 5: Figure S1 and Addithenal file 6: Figure S2).
This was confirmed by LC3B expression levels and highly accumulated autophagy substrate p62 levels in the western blots (Fig. 1b) and confocal imaging (Fig. 1c).
With the development of boron containing agents and the optimization of strategies of delivery, [B] can be highly accumulated in tumor cells and the level in normal cells becomes relatively lower [ 2, 13, 35, 36].
ATD analysis revealed that RNAPII and H3K4me3 were highly accumulated on TSSs of these genes, and that H3K4me2 localization is broader than localization of RNAPII and H3K4me3, and accumulated on the region surrounding TSSs of these genes (Fig. 3b).
Orally administered RNPO highly accumulated in colonic mucosa, and specifically internalized in cancer tissues, but less in normal tissues.
