Sentence examples for highly aberrant from inspiring English sources
Notably, we investigated mutations to RNA polymerase, which provided a massive growth benefit but are linked to highly aberrant transcriptional profiles.
These span 745 mb of sequence and therefore the likelihood of CNV overlapping cancer-specific loci in a highly aberrant tumor type are high.
Evident cases of sequencing errors (type Ib) are the highly aberrant AF448225 sequence (Pseudoperonospora cubensis) as well as the Peronospora tabacina sequences DQ067900 and DQ067899 with many ambiguous bases.
Changes in DNA methylation status are associated with X-inactivation, imprinting, and the development of primordial germ cells [2] [5]; moreover, DNA methylation is highly aberrant in cancer [6] [9].
In HeLa cells, depletion of Apc2, an essential component of the catalytic center of the APC/C, results in highly aberrant anaphase progression, but does not prevent sister chromatid separation [35].
However, in contrast to the PD1cDNAint1-2/Bam containingcontaintronsntrons 1 and 2, expression was barely detectable in PBL (Figure 1A, bottom panel) and highly aberrant in other tissues relative to the genomic transgene: Expression was disproportionately high in brain and low in spleen, relative to liver, as assessed by RT-PCR or by northern (Figure 1D).
It is well known that the least square approach is highly sensitive to aberrant points, which implies that FCM gives unsatisfactory results when it is applied to data sets contaminated with noise and outliers.
Unsolved topological constrains lead to highly recombinogenic and aberrant DNA transitions, DNA entangling, and breakage.
Premature infants are highly vulnerable to aberrant gastrointestinal tract colonization, a process that may lead to diseases like necrotizing enterocolitis.
TGFß-recruited macrophages are highly phagocytic for aberrant cells and thereby decrease the ability of tumor antigens to be delivered to the adaptive immune system [ 10].
In general, there appear to be genomic locations which are highly susceptible to aberrant DNA methylation during toxicant-mediated malignant transformation.
