While Frantal and Kunc [37] found no significant influence of WT construction on the number of visitors to recreation areas in the Czech Republic, other studies have highlighted marked opposition and disagreement among the general public concerning popular recreation areas [8, 10].
Real-space correlation coefficients (Brändén and Jones, 1990) highlighted marked local improvements for flexible residues in particular with 11 residues improving by more than 0.1 in correlation coefficient.
Although the zebra finch MHC assembly remains fragmented, the patterns revealed by this analysis highlight marked differences between zebra finch and chicken.
Our microarray analysis highlighted marked changes in several molecular pathways in CM-S compared to CM-R mice, particularly at early stages of infection.
Both domains, and each pair of transmembrane regions within domain I, were capable of forming oligomers, highlighting marked redundancy in the molecular determinants driving oligomer formation.
All have highlighted marked heterogeneity in the available literature, with most studies being single centre and involving relatively small patient numbers.
In addition, K-Ras, B-Raf and PIK3CA mutation burden ranged from 11 to 99%, 12 to 65% and 14 to 54% of cells, respectively, highlighting marked inter-tumour heterogeneity in mutation burden.
Studies in the USA, however, have highlighted marked ethnic variations in breast cancer survival (Young et al, 1981; Richardson et al, 1992; Eley et al, 1994; Hsu et al, 1997; Hunter, 2000).
Indeed, previous genome sequencing studies have reported few common mutations between different tumour foci within the same prostate (Lindberg et al. 2013), highlighting marked intra-tumour heterogeneity and the absence of a genetic founder mutation.
