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That mild initial clinical illness progresses to severe sepsis and death despite appropriate clinical care highlights host responses to sepsis that differ between survivors and non-survivors.
Fig. 3D (and Supplemental Table S15) highlights host proteins, including several surface receptors, that are likely to interact with PAN domain-containing parasite proteins.
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However, recent studies have highlighted host heterogeneity in the development of this immune response, characterized by delay and even absence of protection, that could lead to homologous reinfection (HR).
All these examples illustrate how the integration of evolutionary data into an immunological framework can provide important insights into genes playing a major biological role for past and present survival and highlight host pathways playing an essential role in pathogen resistance.
The genome sequence of P. acnes and subsequent studies have highlighted host-interacting factors such as CAMP factors, hemolysins, sialidases and dermatan-sulphate adhesins [ 16- 20].
His résumé highlights a host of publications on subjects including information modeling, neural networks and data mining.
Among the week's other highlights: Black Host, an ensemble led by Mr. Cleaver, on Tuesday at 10 p.m.; a quartet jointly led by Mr. Berne and the trumpeter Baikida Carroll, on Wednesday at 10 p.m.; and These Arches, the signature band of Mr. Smith, on Thursday at 8 p.m.
While the report cites "reasonable progress" in work on U.S. space station elements, it also highlights a host of technical challenges--such as the complexity of assembling the station in orbit--that threaten to derail NASA's schedule.
The trade policy agenda also highlights a host of other environmentally-oriented trade priorities, from promoting sustainable tropical timber trade to reducing subsidies that contribute to overfishing.
A series of reports in recent weeks have highlighted a host of failures by both industry and regulators.
They designed the test after a major study into the genetic makeup of centenarians highlighted a host of DNA variants that boost a person's chances of reaching a ripe old age.
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