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Moreover, the intron 7 SNPs have some level of LD with the intron 1 and 2 SNPs (r2>0.6), though the intervening SNP13494 site in intron 6 was not linked with them, highlighting gene rearrangements in the p53 gene.
These data provide the basis for subsequent correlation analysis aimed at highlighting gene co-regulation and metabolic networks [ 85].
DOI: http://dx.doi.org/10.7554/eLife.08527.032 10.7554/eLiFigure27.033 Figure 5 figure supplement 2. Co-expression map showing fold changes of 10.7, 22, 45.4 and 72.3 hr compared to the young reference, highlighting gene products contributing to gene enrichments.
The regulation of 90 genes was confirmed by quantitative real time polymerase chain reaction (qRT-PCR) revealing 3 main expression patterns and highlighting gene regulation that occurs downstream of R protein activation.
This process has been significantly aided with the recent completion of the P. marneffei genome sequence (Alex Andrianopoulos and William C. Nierman, unpublished data), highlighting gene groups common to dimorphic fungi as well as genes unique to P. marneffei.
A Cytoscape plugin, BioNetBuilder (Avila-Campillo et al., 2007), can also be used to import KEGG data into Cytoscape but (i) it merges all KEGG interactions into a single network, making its exploration difficult, (ii) it does not provide a simple way to integrate expression data and (iii) it does not produce a visualisation highlighting gene expression changes.
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The latter analysis measures the overall association evidence across a gene, highlighting genes with multiple association signals.
Figure 4 shows a scheme of the glycolytic pathway, highlighting genes down regulated by daunorubicin.
Primary auxin responsive gene families (GH3, SAUR, LBD) show different phylogenetic profiles in P. patens, S. moellendorffii and flowering plants, highlighting genes for further study.
Most studies take a gene-based approach to identifying driver mutations, highlighting genes mutated in a large percentage of tumor samples as those likely to contain driver mutations.
Gene Ontology analysis highlighted gene expression during acute dehydration response depending on organ types and the duration of stress.
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CEO of Professional Science Editing for Scientists @ prosciediting.com