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A similar analysis in BRCA1 vs BRCA2 tumours highlighted increase in PPI co-expression around the mitotic regulators CDK1, CDC20 and CKS1B and the histone deacetylases HDAC1 and HDAC6; these are known drug targets for which inhibitors have been developed [ 61, 62].
This possibly explains the highlighted increase in EDNOS diagnoses in the latter part of the 2000s, maybe secondary to the increased research carried out on EDNOS resulting in the increased awareness to the wider spectrum of ED that do not fit into the diagnoses of AN and BN.
With these technological advances in mind, the Plant Science Decadal Vision has highlighted 'Increase the ability to predict plant traits from plant genomes in diverse environments' and 'Enhance the ability to find answers in a torrent of data' as two of its five goals to shape plant biology research in the decade 2015 2025.
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Farage has also highlighted increases to defence spending as a key priority in any deal.
The report also highlighted increases in the marriage age for men and women, a long-term trend that began in the 1950s.
The report also highlighted increasing spending by boards on costly agency workers because of significant problems with recruitment and retention of staff, as well as a lack of workforce planning for new models of care to deliver more community-based services.
Previous studies have similarly highlighted increased macrophage infiltration in epicardial fat [ 22].
The profound shunt-induced hypoxemia has been recognized for decades [ 21], but recent publications have highlighted increases in the dead space fraction as well [ 15, 22].
Research has also highlighted increased use of CAM by rural populations when compared to urban populations, both in Australia and internationally [ 22, 23].
PCFG highlighted increasing difficulties associated with multiple care providers working in apparent isolation as a major difficulty in ensuring holistic care.
Indeed, ChIP experiments on both lymphoblastoid cell lines and fibroblasts from premutation carriers and FXTAS patients have highlighted increased levels of acetylated H3K9 and H4 in the regions directly surrounding the CGG repeats.
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