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These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response.
The review also highlighted difficulty interpreting toxicity of the ethylmercury in thiomersal because guidelines for mercury toxicity were based primarily on studies of methylmercury, a different mercury compound with different toxicologic properties.
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The analysis highlighted difficulties in demonstrating value for money and concludes that the bidding process can be an unequal struggle between large consortia and inexperienced clients that may result in a wasted opportunity to obtain the optimum design and price.
This highlighted difficulties in communication about plants, the replication of their descriptions, and the importance of an agreed way of presenting, publishing and applying their names.
Recent publications in both the medical and mainstream press have further highlighted difficulties and barriers to undertaking medical research [ 8- 10].
Cognitive debriefing of the selected PRO measures of pain severity highlighted difficulties among patients in understanding the verbal response scale (VRS) of the MPQ PPI scale.
Literature from mental health units has also highlighted difficulties with diagnosing mental health problems in patients from different cultural backgrounds [ 34].
A previous report has also highlighted difficulties in recruiting individuals from minority ethnic communities and suggests that a range of methods may be necessary in order to maximise response rates [ 21].
In addition to delays in patient help-seeking, clinicians highlighted difficulties applying the TWW referral criteria for CRC, and concerns over the stringent application of waiting time targets (and associated penalties for breaching targets) which were perceived as potentially compromising patient-centred care.
(lactation expert, France) In the Trent region, our informants highlighted difficulties in helping mothers to maintain their milk supply, and the need to improve follow-up of mothers who initiate milk expression: Making sure that the mother does it better in the long term rather than just focusing on that first week to ten days.
Some participants reported good links and received adequate numbers of referrals, while others highlighted difficulties in engaging HVs: They don't understand the programme, so they don't refer in, it's really hard to get them on board, and if they've got shortages within their team, the last thing they're thinking about is referring to us.
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