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Both the XAS and biochemical assay results of this investigation highlighted alterations in sulfur speciation, with increased disulfides (XAS) or increased disulfide to thiol ratio (biochemical assay) as a consequence of a 2 min PMI (relative to <30 s).
The GEP data also highlighted alterations in signaling associated with PTH treatment in myelomatous bone.
So why have these studies highlighted alterations in metabolism and responses to stress, rather than alterations in the DAP complex?
Two previous studies have highlighted alterations in autophagy associated with the G2019S mutation at an endogenous level [18,20].
Regarding PND21 brain extracts, recent studies have highlighted alterations in brain development following perinatal exposure to BPA (Itoh et al. 2012; Kunz et al. 2011).
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These observations have implicated specific recombination proteins and also highlighted other alterations, such as defects in mismatch repair, that may similarly influence the survival of human cells that fail to express telomerase.
This proof-of-principle experiment revealed that subclones in each GBM had variable regenerative or stem cell activity, and highlighted genetic alterations associated with more competitive propagating activity in vivo.
In the last decade, high-throughput analyses of transcriptomes have highlighted widespread alterations of AS patterns in human cancer [ 21, 22].
RVA analysis, carried out on whole wheat flour, highlighted large alterations in chemical-physical properties of transgenic starch.
Serine mediated hydrolysis/cleavage by the enzyme has been highlighted and alteration of enzyme configuration under varying pH induced by nanoclays has been projected.
Previous studies have highlighted that DNA methylation alterations are widespread in invasive breast carcinoma and result in cellular dysfunction [ 14– 14].
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