Taken together, our data suggest that busulfan may have an anti-osteosarcoma effect through downregulating ZEB1 and ZEB2 through activating the miR-200 family, highlighting a possibility of using busulfan as a novel therapy for osteosarcoma.
Taken together, our data suggest that busulfan may produce its anti-osteosarcoma effect by downregulating ZEB1 and ZEB2 through activating the miR-200 family, highlighting a possibility of using busulfan as a novel therapy for osteosarcoma.
The new finding that loss of p53 activates the IRE1α/XBP1 pathway leading to enhanced ER function broadens our understanding of how cancer cells with mutant p53 survive, and also highlights a possibility for the development of novel therapeutic strategies.
Italy's economic and political situation has highlighted a range of unpleasant possibilities for the European Union.
The authors wish to highlight a few possibilities that could lead to the current limited mouth opening: First, failure to address the ipsilateral and/or contralateral coronoid process; Second, undissected tendon of the masseter and medial pterygoid muscles [ 4]; and Third, lack of compliance to post-operative aggressive physical therapy.
The findings highlight a possibility for hyperactive HDAC I/II to intervene with various PARP types, perhaps causing abnormal stimulation of these enzymes.
The near-significant result for IL28B-917 SNP highlights a possibility of nonrandom clustering of host genetic effects on the phylogeny, which could have affected our previous analysis on infection outcome status.
This knowledge also highlights a great number of possibilities to combine drugs from different therapeutic classes for systematic management of chronic diseases (31).
At the same time, they indicated potential phenotypic differences when compared with other constitutive and conditional GlyT1 knockout lines, and highlighted the possibility of a functional divergence between the neuronal and glia subpopulations of GlyT1 in the regulation of learning and memory processes.
All of the above information established the importance of the igr operon for cholesterol metabolism by Mtb and highlighted the possibility that a second heteromeric structural motif may be encoded in the operon.
