Finally, we highlight network-related drug development trends helping to achieve these hallmarks by a cohesive, global approach.
However, we mention it as an example of how this approach may highlight networks of proteins, where subtle modification of multiple partners may result in cumulative disruption that would lead to disease under a multiplicative burden of rare variants model.
Additionally, another paper has described the importance of protein-protein interaction network topology in identification of interaction targets of pathogens [ 10] and a recent study of the interaction networks surrounding HCV-specific interaction targets also highlighted network topology [ 21].
I will briefly review the current state of knowledge of circadian system and mood regulation, highlighting network properties and system dynamics as key mediators of neural plasticity, which underlies the circadian rhythm-mood connection.
In this review, we attempt to highlight the network perturbations that occur in "typical" aging and emphasize how they may differ from those that manifest in dementia.
Functional imaging offers a valuable complement to the neuropsychological approach, providing a way to highlight the network of areas associated with the normal performance of a given function.
Results from DREAM highlight that network inference is a challenging problem.
Further, and perhaps most importantly, the specific pathway we highlight as network signature can be carried over to new datasets.
