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In H. capsulatum, the dimorphic transition rate at 37°C was found to be a key factor in the pathogenicity of three strains with different degrees of virulence that were studied, as that with the highest virulence was transformed to the yeast phase (virulent) more quickly [ 31].
Furthermore, the virulent HPs present in the set of 83 functionally annotated proteins were predicted by using the Bioinformatics tools and the conformational behaviours of the proteins with highest virulence scores were studied by using the molecular dynamics (MD) simulations.
However, if bacteria co-operate, i.e. use exoenzymes to extract nutrients, high relatedness (low diversity) is expected to lead highest resource use and thus also highest virulence [38].
In this study, the virus with the special NA stalk-motif (NA-wt) possessed the highest virulence and pathogenicity in chicken and mice.
Our data supports the former hypothesis because highest virulence was attained with least diverse mixture of clones, i.e. with the ancestor strain (Fig. 3b).
The recombinant H5N1 virus with the special stalk-motif possesses the highest virulence and pathogenicity in chicken and mice, while the recombinant viruses with the other stalk-motifs display attenuated phenotype.
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All virulent stocks used to perform these experiments showed high virulence in vivo.
Other studies say Soviet military labs also tested typhus, botulinum toxin, Venezuelan equine encephalitis, smallpox, and microbial strains with characteristics useful in warfare, like high virulence and resistance to ultraviolet rays or heat.
The symbioses, whether mutualism or parasitism, benefit the higher virulence species.
This could be attributed to multiple factors including high virulence of the organism and delayed presentation of the patients.
The necessary dose for induction of S. aureus osteomyelitis is low due to the high virulence of the pathogen.
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