Sentence examples for highest tolerated dose from inspiring English sources

It is recommended to escalate the dose of cholinesterase inhibitors to the highest tolerated dose within the approved dose range for better outcomes.

In TEMPO 4 4, 871 subjects from the lead TEMPO 3 4 trials (tolvaptan, 557; placebo, 314), received open-label tolvaptan at their highest tolerated dose for a minimum of 24 additional months.

In large clinical trials, ivabradine has been investigated as an alternative to beta-blockers, when these agents cannot be tolerated or are contraindicated, or in addition, when HR is not adequately controlled with the highest tolerated dose of beta-blockers.

The dose was chosen as the highest tolerated dose (because of blood pressure reduction) based on reports in the literature [14, 15].

Adults with moderate to severe peripheral neuropathic pain entered a 3- to 4-day screening period, followed by a 12-day titration to the highest tolerated dose that provided pain control (pregabalin 50 200 mg t.i.d)., and then a 9-day maintenance period.

The general aim was to reach the highest tolerated dose of intravenous iloprost.

The F.D.A. said a further clinical test was needed in patients who are resistant to other hypertension drugs used in combination at their highest tolerated doses.

These studies utilize the highest tolerated doses in multiple animal species and develop dose response curves to assess no observed effect (NOEL) or no observed adverse effect levels (NOAEL) for a variety of physiological endpoints.

MTD was defined as the highest safely tolerated dose with toxicity levels that did not exceed any of the following DLTs at one dose level: grade III hematologic toxicities (≤ 2 of 6 patients); grade III cardiac or pulmonary toxicity (≤ 2 of 6 patients); grade III esophagitis (≤ 2 of 6 patients) and other unexpected, relevant grade III toxicities (≤ 2 of 6 patients).

The four times higher maximally tolerated dose in ILP resulted in a 4-5 times higher peak concentration of mitomycin C in liver tissue, while the plasma concentration remained significantly lower than in the HAI treated rats.

This is exemplified by the remarkably high maximum tolerated dose observed for PK1 in clinical trials, being >5 times higher than that determined for free doxorubicin (320 vs 60 mg m−2; Vasey et al, 1999).